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Synaffix has expanded the utility of it clinical-stage GlycoConnect™ platform to also deliver immune cell engagers. Key highlights of corresponding AACR poster:

  • GlycoConnect™ technology enables site-specific attachment of both cytotoxic payloads and small protein fragments to antibodies without genetic engineering
  • Small protein fragments (like scFvs) can be attached to generate bispecific T cell engagers with tailored stoichiometry, where the 2:1 format may be of particular interest to minimize cytokine release syndrome (CRS)
  • Trimming the antibody glycan fully abrogates binding to Fc-γ receptors, thus nihilating effector function