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Synaffix Wins ‘Best ADC Platform Technology’ Award

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AMSTERDAM, NETHERLANDS – Synaffix B.V., a biotechnology company enabling antibody-drug conjugates (ADCs) with best-in-class therapeutic index, announces that it has won the “Best ADC Platform Technology” category at the 2020 World ADC Awards ceremony.

Synaffix’ ADC platform consists of GlycoConnect™, HydraSpace™ and toxSYN™ which comprise site-specific technology and payloads to enable best-in-class ADCs.

Synaffix was presented the award during the 2020 World ADC Digital event.  The finalists were shortlisted through a voting pool of over 1,000 individuals, with a panel of distinguished, independent industry experts from across the ADC field, assessing each finalist to decide the winners.

The judging panel highlighted the following three cornerstone features of the Synaffix ADC platform:

  • Consistent delivery of highly competitive ADC product candidates
  • Strong commercial and scientific validation (over $420m in out-licensing deals,at least six ADCs in development with two in clinical trials)
  • Compatible and easy to use with any antibody

For the full list of winners, see https://worldadc-awards.com/.

Peter van de Sande, CEO of Synaffix said:

“We are greatly honored to be recognized with the award for Best ADC Platform Technology as voted by our industry peers.” 

“Our team has worked passionately to provide cutting-edge ADC-enabling technologies, and we have now built what we believe to be an industry-leading platform to enable best-in-class ADC product candidates.”

“Being recognized with this award serves to validate the significant efforts we have already made towards becoming the most prevalent technology across new clinical-stage ADCs.”

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Protein Conjugates

Bring your own and/or choose from the following categories. 

 

Just like our ADC technology, we can easily attach peptide and protein-based payloads to your antibody.

 

Early preclinical data available on request.

Bring Your Own

scFv / Fab
Cytokine

Immune Cell Recruiters

Anti-CD3

T cell recruitment
IL-15

NK cell recruitment

IL-15 Receptor Fusion

NK cell recruitment

HydraSpace™ Polar Spacer

Forming an integral part of every toxSYN™ linker-payload, HydraSpace™ bears a negative charge at physiological pH and improves:

  1. Therapeutic efficacy
  2. Tolerability
  3. PK
  4. Manufacturability
Key publication about HydraSpace

GlycoConnect™ design easily matches payload potency with the most appropriate drug-antibody ratio (DAR).

Key publications about GlycoConnect™

toxSYN™ Linker-Payloads

Choose from the following linker-payloads, attach to your antibody under a technology evaluation and go straight into ADC product development following positive POC.
toxSYN™
Linker-Payload
Mode-of-Action Payload
(Active Catabolite)
1. SYNtecan E™*Topoisomerase 1 inhibitor Camptothecin-based
2. SYNeamicin D™*DNA
damaging agent
Calicheamicin-based
3. SYNeamicin G™*
4. SYN-PNU™*Nemorubicin-based
5. SYNstatin E™Microtubule
inhibitors
Auristatin-based
6. SYNstatin F™
7. SYNtansine™ Maytansine-based

* Patent protection filed by Synaffix, beyond the claims of GlycoConnect™ and HydraSpace™

** N-6-aminohexanoyl-maytansine (Ahx-maytansine)