Our clinical-stage technology platform
enables ADCs that are safer, more effective
and easier to manufacture

About Synaffix


Formed in 2010, Synaffix BV is a Netherlands-based biotechnology company exclusively focused on continued advancement of our best-in-class, clinical-stage antibody-drug conjugate (ADC) technology platform. As a leading innovator in the field of ADCs offering absolute versatility and state-of-the-art solutions, our vision is to become the preferred partner in the development of these complex biological therapeutics and realize our ambition – connect to cure.

We are backed by a top tier, life science-focused investor syndicate including Aravis, BioGeneration Ventures, BOM Capital and M Ventures.

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Corporate Fact Sheet (PDF)

Our antibody conjugation technology, GlycoConnect™, enables the design of complex biological drugs without the need for prior genetic modification and with specificity and precision similar to what is used to design modern small molecule drugs.  Combined with our payload-enhancing linker technology, HydraSpace™, and the superior stability and efficacy offered by our proprietary BCN-based metal-free click chemistry, the resulting ADCs come with an expanded therapeutic index (TI) and improved manufacturability.  Most recently, our underlying platform has been expanded with the addition of the toxSYN™ ADC payload platform which includes 4 different payloads that our collaborators may use to build proprietary ADCs for their pipelines.

Our technology is mature enough to allow initiation of clinical trials within a year from the preclinical proof-of-concept.  We anticipate the first-in-human studies with glycan-conjugated ADCs to be initiated by our partners in 2018.

About us

Formed in 2010, Synaffix BV is a Netherlands-based biotechnology company exclusively focused on continued advancement of our best-in-class antibody-drug conjugate (ADC) technology platform.

As a leading innovator in the field of ADCs offering absolute versatility and state-of-the-art solutions, our vision is to become the preferred partner in the development of these complex biological therapeutics and realize our ambition – connect to cure.

We are backed by a top tier, life science-focused investor syndicate including Aravis, BioGeneration Ventures, BOM Capital and M Ventures.

Our antibody conjugation technology, GlycoConnect™, enables the design of complex biological drugs without the need for prior genetic modification and with specificity and precision similar to what is used to design modern small molecule drugs. Combined with our payload-enhancing linker technology, HydraSpace™, and the superior stability and efficacy offered by our proprietary BCN-based metal-free click chemistry, the resulting ADCs come with an expanded therapeutic index (TI) and improved manufacturability. Most recently, our underlying platform has been expanded with the addition of the toxSYN™ ADC payload platform which includes 4 different payloads that our collaborators may use to build proprietary ADCs for their pipelines.

Our technology is mature enough to allow initiation of clinical trials within a year from the preclinical proof-of-concept. We anticipate the first-in-human studies with glycan-conjugated ADCs to be initiated by our partners in 2018.

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Technology

The Synaffix IP portfolio is comprised of 20 patent applications and granted patents that are necessary and useful to generate and sell Synaffix ADCs. Filed and granted claims cover key aspects of Synaffix ADC technology.

GlycoConnect™

HydraSpace™

toxSYN™ Payloads

Metal-Free Click

Leadership

Management Team

Board of Directors

Scientific Advisory Board

Investors

Partnerships

Our vision is to be the preferred technology partner by providing a one-stop solution that enables any company with an antibody to rapidly generate a proprietary clinical-stage ADC that is significantly more effective, better tolerated as well as easier to manufacture.

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News & Media

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Contact

Synaffix BV
Kloosterstraat 9
5349 AB Oss, Netherlands

+31 88 022 4505 (tel)
+31 88 022 4555 (fax)

info@synaffix.com